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Seiha Yen, Melissa Preissner, Ellen Bennett, Stephen Dubsky, Richard Carnibella, Ronan O’Toole, Louise Roddam, Heather Jones, Peter A. Dargaville, Andreas Fouras, and Graeme R. Zosky

The aim of this study was to assess the association between regional tidal volume (Vt), regional functional residual capacity (FRC), and the expression of genes linked with ventilator-induced lung injury. Two groups of BALB/c mice (n = 8 per group) were ventilated for 2 hours using a protective or injurious ventilation strategy, with free-breathing mice used as control animals. Regional Vt and FRC of the ventilated mice was determined by analysis of high-resolution four-dimensional computed tomographic images taken at baseline and after 2 hours of ventilation and corrected for the volume of the region (i.e., specific [s]Vt and specific [s]FRC).