Challenges in small molecule crystallography
Some of the biggest challenges in small molecule crystallography measurements are when the crystal is too small or too thin or if the crystals are heavily twined and not well diffracting. In these cases, using a conventional X-ray source would be very difficult, time consuming or even impossible.
The option then could be to use a diffractometer equipped with a MetalJet X-ray source and a hybrid photon counting detector.
“If the data collection is not successful with the conventional X-ray diffractometer, I run the test again with the high intensity MetalJet and PILATUS combination to get much better quality data.”
Dr. Alessandro Prescimone