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Seiha Yen, Melissa Preissner, Ellen Bennett, Stephen Dubsky, Richard Carnibella, Rhiannon Murrie, Andreas Fouras, Peter A. Dargaville, and Graeme R. Zosky

Both overdistension and atelectasis contribute to lung injury and mortality during mechanical ventilation. It has been proposed that combinations of tidal volume and end-expiratory lung volume exist that minimize lung injury linked to mechanical ventilation. The aim of this study was to examine this at the regional level in the healthy and endotoxemic lung.