The researchers at Institute of Physics and Engineering in Medicine at Monash University in Australia have successfully been able to transform the in-vivo 4D-CT on pulmonary vasculature in small animals from synchrotron facilities to laboratory with the high brightness microfocus MetalJet X-ray source. Based on this and in conjunction with the dedicated post-image analysis, the quantitative information about the morphologies and dynamics of pulmonary vasculature tree in mice have been extracted. This also indicates that imaging modality can be a complementary methodology added to other in- and ex-vivo studies on murine pulmonary vasculature in small animal models.
Application of a novel in vivo imaging approach to measure pulmonary vascular responses in mice
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