How 3D virtual histology based on µCT helps to understand Covid-19
Date: April 14
Time: 3 pm CEST
Speaker: Dr. Tim Salditt, Professor of Experimental Physics, head of research group Structure of Biomolecular Assemblies and X-ray Physics, Institute of X-ray physics, University of Göttingen.
Severe progression of Covid-19 is frequently accompanied by lethal respiratory failure. The underlying lung injury can already be detected by radiographic chest imaging and clinical computed tomography (CT). However, in order to study disease mechanisms at the cellular level, a much higher resolution is required. For this purpose, phase-contrast X-ray CT has been used such that three-dimensional imaging tasks can be performed non-destructively on lung autopsies or biopsies. The team at the University of Göttingen has implemented this both with synchrotron radiation and at their in-house MetalJet source to investigate tissue samples from Covid-19 patients, as well as healthy control samples.
In this talk, Professor Salditt will present the status of the project, the pathological relevance, and the technical challenges concerning data acquisition, reconstruction and analysis. He will finish with an outlook on how 3D virtual histology and patho-histology can be further developed and be applied to biomedical research, with an emphasis on compact laboratory instrumentation.