Structural insights into the potency of SK channel positive modulators

Sci Rep. 2017; 7: 17178. Published online 2017 Dec 7. doi:  10.1038/s41598-017-16607-8 
Young-Woo Nam, Razan Orfali, Tingting Liu,  Kunqian Yu,  Meng Cui, Heike Wulff, and Miao Zhang
A group from Chapman University School of Pharmacy have used a Bruker D8 Venture system with a MetalJet X-ray source to study a Small-conductance Ca2+-activated K+ (SK) channel. The interaction between four compounds acting as positive modulators and their binding pockets in the SK channel was investigated and a strong trend between interaction energy and the potency of the compounds was shown.


Link to article in PDF here


By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept", you are consenting to this.