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Applications

Here we present only a sample of applications. Please, discuss your projects with us should you need more guidance regarding suitable applications!

 

 

Small Molecule Crystallography

extended network small molecule structure  

Small molecule crystallography uses X-ray diffraction in the determination and study of the three dimensional structure of a material at the atomic and molecular scale. A single crystal of the sample is required and the resulting X-ray structures provide a to scale 3D visual map of the atom types, their relative arrangement and how they are connected in space. The crystal samples studied are typically, inorganic, organic or organo-metallic compounds, primarily from research in the disciplines of Chemistry, Geology and Physics.

As small molecule X-ray crystallography becomes more automated and routine, there is increasing interest in the study of more difficult and specialist materials where a high brilliance MetalJet X-ray source is desirable. Use of the MetalJet typically means shorter experiment times, faster structures and higher throughput of samples. Small and weakly diffracting crystals, diffract more strongly providing higher quality data, whilst sensitive crystals can be measured faster with the MetalJet and suffer less degradation accordingly. Twinned crystal data can be more strongly defined using a MetalJet, making it more easily identified and potentially handled. Very weak diffraction effects, inherent to incommensurates, diffuse scattering samples, quasi-crystals and high pressure samples become stronger and may be more readily measured and investigated using the high brilliance X-rays of a MetalJet.

   

 

Protein Crystallography

ligand binding campylobacter protein

 

 

Protein crystals are extremely sensitive and poorly defined, due to the extremely large proportion of water within their structures. As a result, protein structures are ‘floppy’ and the X-ray diffraction data is typically of a much lower resolution quality compared to a small molecule structure. At the same time, the number of atoms present in a protein structure is extremely large and the data (Bragg reflections) to be collected is very closely packed together.

Protein crystallographers rely on the strongest X-ray sources to combat the issues of air sensitivity, small crystals, low diffraction and densely packed reflections. Traditionally, a high brilliance synchrotron has been used to measure full protein data leading to protein structure determination, whilst home laboratory instruments have been used for protein screening to identify the preferred crystals for measurement at the synchrotron. 

High brilliance X-ray sources, such as the MetalJet have made a greater number of protein structures and experiments possible in the home laboratory, thereby accelerating research with ease of access and convenience.Using the high brilliance MetalJet X-ray source makes weak diffraction data stronger, reducing experiment times and potentially reducing sample degradation. The narrow, focused X-ray beam is ideally suited to measuring even the smallest protein crystals, providing compact and well-defined reflections. The higher intensity MetalJet X-rays typically extend the angular resolution limit of the visible protein data collected and provide more precise reflection positions and intensities, leading to higher resolution protein structures.

   

 

Small Angle X-ray Scattering (SAXS)

saxs protein bio saxs image  

Small molecule crystallography uses X-ray diffraction in the determination and study of the three dimensional structure of a material at the atomic and molecular scale. A single crystal of the sample is required and the resulting X-ray structures provide a to scale 3D visual map of the atom types, their relative arrangement and how they are connected in space. The crystal samples studied are typically, inorganic, organic or organo-metallic compounds, primarily from research in the disciplines of Chemistry, Geology and Physics.

As small molecule X-ray crystallography becomes more automated and routine, there is increasing interest in the study of more difficult and specialist materials where a high brilliance MetalJet X-ray source is desirable. Use of the MetalJet typically means shorter experiment times, faster structures and higher throughput of samples. Small and weakly diffracting crystals, diffract more strongly providing higher quality data, whilst sensitive crystals can be measured faster with the MetalJet and suffer less degradation accordingly. Twinned crystal data can be more strongly defined using a MetalJet, making it more easily identified and potentially handled. Very weak diffraction effects, inherent to incommensurates, diffuse scattering samples, quasi-crystals and high pressure samples become stronger and may be more readily measured and investigated using the high brilliance X-rays of a MetalJet.

   

 

X-ray photoelectron spectroscopy (XPS)

media WEB HAXPES Lab DSC 76033491 20180111 175737 omicronmedia image paddedthumbnailscheme ffffff 173x223  

HAXPES-Lab is designed to allow hard X-ray photoelectron spectroscopy (HAXPES) measurements in standard lab environments and offers the unique possibility to investigate bulk properties of various materials, analyse buried interfaces and access deep core levels.

Photoelectron spectroscopy is an ideal tool to probe the chemical state of a material and as such it is becoming ever more used to investigate electronic structures of various solid materials in the bulk, on surfaces as well as at buried interfaces. A home laboratory facility that probes bulk and buried interfaces has up until now not been commercially available.

To read more about this product, please visit our partner Scienta Omicron!